Research Grants Funded by
the National Niemann-Pick Disease Foundation
| Item # (in Descending Order) |
Date | Researcher | Project | Additional Information |
|---|---|---|---|---|
| 48 | 4/1/2008 - 3/31/2009 | Edward H. Schuchman, PhD
(Mount Sinai School of Medicine, New York,NY, USA) (1 Year) |
Construction & Characterization of New Mouse Models
for Types A & B Niemann-Pick
$46,593 Partial Funding |
More Details... |
| 47 | 3/1/2008 - 2/28/2010 | Fran Platt & Emyr Lloyd-Evans
(University of Oxford, Oxford, UK) (2 years) |
Targeting sphingosine storage as a new therapeutic approach for Niemann-Pick type C
$161,097 Partial Funding |
More Details... |
| 46 | 4/1/2007 - 3/31/2008 | Multiple
(Lysosomal Storage Disease Research Consortium) (1 year) |
Additional contribution to LSD Research Consortium for research into issues of common interest to all LSD support groups (See also Grant # 40) $10,000 |
More Details... |
| 45 | 3/1/2007 - 2/29/2008 | Frances M. Platt
(University of Oxford) (1 year) |
Evaluation of anti-inflammatory intervention (NSAIDS) as an adjunctive therapy in Niemann-Pick Type C1 disease.
$99,090 |
More Details... |
| 44 | 4/1/2006 - 3/31/2007 | Multiple
(Lysosomal Storage Disease Research Consortium) (1 year) |
Additional contribution to LSD Research Consortium for research into issues of common interest to all LSD support groups (See also Grant # 40) $10,000 |
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| 43 | 9/1/2006 - 8/31/2007 | Maria D. Ledesma, Ph.D.
(Catholic University of Leuven; Leuven; Belgium) (1 year) |
Analysis of Dendritic Spine Alterations in Niemann-Pick Disease Type A Neurons
$19,760 Bridge Funding |
More Details... |
| 42 | 6/1/2006 - 12/31/2007 | Kostantin Dobrenis, Ph.D.
(Albert Einstein College of Medicine of Yeshiva University; Bronx, New York; USA) (18 months) |
Establishment of Central Nervous System Cell Lines from NPC-1 Disease Mice for Pathogenic and Therapeutic Studies
$80,240 |
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| 41 | 5/1/2006 - 11/30/2006 | Frances M. Platt, Ph.D.
(University of Oxford; Oxford, England; UK) (7 months) |
Therapeutic Monitoring of Glycolipid Storage Diseases in the Clinic Using Cell Biological Assays and Proteomics
$50,000 Bridge Funding |
More Details... |
| 40 | 4/1/2004 - 3/31/2006 | Multiple - See "More Details"
(Lysosomal Storage Disease Research Consortium) |
Lysosomal Storage Disease Research Consortium
Contribution for NNPDF to Join Consortium
$10,000 |
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| 39 | 4/15/2005 - 4/14/2006 | Robert A. Maue, Ph.D.
(Dartmouth Medical School; Hanover, New Hampshire; USA) (1 year) |
Maintenance of Colony of NPC1 mice with GFP-tagged Purkinje neurons
$6,000 Bridge Funding |
More Details... |
| 38 | 5/1/2005 - 4/30/2006 | Thomas J. Kelley, Ph.D.
(Case Western Reserve University; Cleveland, Ohio; USA) (1 year) |
NOS2 regulation in NPC
$55,000 Major funding provided by the Niemann-Pick Disease Group (UK). |
More Details... |
| 37 | 4/1/2005 - 4/1/2007 | Richard E. Pagano, Ph.D. and David L. Marks, Ph.D.
(Mayo Clinic and Foundation; Rochester, Minnesota; USA) (2 years) |
Reduction of stored lipids in Niemann-Pick Type C mice by rab protein expression
$177,562 |
More Details... |
| 36 | 9/15/2004 - 9/14/2005 | Maria D. Ledesma, Ph.D.
(Fundazione Cavalieri Ottolenghi; Turin, Italy) (1 year) |
Organization of Synapses in Niemann-Pick Disease Type A
$50,000 |
More Details... |
| 35 | 4/1/2004 - 3/31/2005 | Synthia Mellon, Ph.D.
(University of California, San Franciso; San Francisco, California, USA) (1 year) |
SSRIs as a potential therapy for NP-C
$50,000 Jointly funded with Dana's Angels Research Trust . Total project cost is: $97,769. |
More Details... |
| 34 | 3/1/2004 - 2/28/2005 | Stuart A. Lipton, M.D., Ph.D.
(The Burnham Institute; La Jolla, California, USA) (1 year) |
NMDA receptor hypofunction in Niemann-Pick disease Type A
$50,000 |
More Details... |
| 33 | 9/15/2003 - 9/14/2004 | Makoto Michikawa, M.D., Ph.D.
(National Institute for Longevity Sciences; Aichi, Japan) (1 year) |
Cellular and Molecular Mechanisms Underlying Neurodegeneration in Niemann-
Pick Type C disease
$50,000 |
More Details... |
| 32 | 7/1/2003 - 8/31/2004 | Timothy M. Cox, MD, FRCP, FMedSci & Robin Henry Lachmann, M.A., M.B., Bchir, Ph.D.
(University of Cambridge; Cambridge, United Kingdom) (10 months) |
Therapeutic Gene Delivery to the Cerebellum in Niemann-Pick Type C
$40,000 (Transitional Funding - used for PostDoc) |
More Details... |
| 31 | 8/15/2002 - 8/14/2003 | Maria D. Ledesma, Ph.D.
(Fundazione Cavalieri Ottolenghi; Turin, Italy) (1 year) |
Niemann-Pick Disease Type A: Molecular Analysis of Neuronal Membrane Maturation and Synapse Formation
$50,000 |
More Details... |
| 30 | 8/1/2002 - 7/31/2003 | Anita H. Corbett, Ph.D.
(Emory University School of Medicine; Atlanta, Georgia, USA) (1 year) |
Functional Analysis of NPC1
$50,000 |
More Details... |
| 29 | 2/15/2002 - 2/14/2003 | Melanie Jean Dobson, Ph.D.
(Dalhousie University; Halifax, Nova Scotia, Canada) (1 year) |
A Yeast System for Analysis of Sterol Trafficking Defects in NPC
$42,000 |
More Details... |
| 28 | 8/15/2001 - 8/14/2003 | Daniel S. Ory, M.D.
(Washington University School of Medicine; St. Louis, Missouri, USA) (2 years) |
The Role of HE1 in Cholesterol Trafficking
$154,147 |
More Details... |
| 27 | 8/15/2001 - 8/14/2002 | Skaidrite Krisans, Ph.D.
(San Diego State University; San Diego, California, USA) (1 year) |
Role of Peroxisomal Cholesterol/Myelin Formation in the CNS Pathology of the NPC Mouse
$50,000 |
|
| 26 | 2/1/2001 - 1/31/2002 | Anthony H. Futerman, Ph.D.
(Weizmann Institute; Rehovot, Israel) (1 year) |
Neuronal Development & Death in Type A Niemann-Pick Disease
$50,000 |
More Details... |
| 25 | 8/15/2000 - 8/14/2001 | Mary Anna Thrall; DMV
(Colorado State University; Fort Collins, Colorado, USA) (1 year) |
Characterization of Feline Niemann-Pick Type C
$40,216 |
More Details... |
| 24 | 9/1/2000 - 8/31/2001 | Yiannis A. Ioannou, Ph.D.
(Mount Sinai School of Medicine; New York, New York, USA) (1 year) |
Functional Characterization of NPC1L1, a Human Homologue of NPC1
$60,000 |
More Details... |
| 23 | 8/15/2000 - 8/14/2003 | Robert A. Maue, Ph.D.
(Dartmouth College) (3 years) |
Analysis of Growth Factor Actions and Membrane Polarity in Neurons from NP-C Mice
$131,988 (No Cost Extension Received in August, 2002; Completion Date Changed to August, 2003) |
More Details... |
| 22 | April, 2000 | Daniel S. Ory, M.D.
(Washington University School of Medicine; St. Louis, Missouri, USA) |
Molecular Cloning of the Niemann-Pick Type C2 Gene
$125,752 |
More Details... |
| 21 | February, 2000 | Cynthia J. Forehand, Ph.D.
(University of Vermont; Burlington, Vermont, USA) |
Glutamate Receptors and Neuronal Degeneration in Niemann-Pick Type C Disease
$27,107 |
|
| 20 | April, 2000 | Lisa D. Griffin, M.D., Ph.D.
(University of California - San Francisco; San Francisco, California, USA) |
Altered Neurosteroidogenesis in Niemann-Pick Type C Disease
$40,000 (Extension of Grant # 16) |
More Details... |
| 19 | February, 2000 | James Shayman, M.D.
(University of Michigan; Ann Arbor, Michigan, USA) |
Treatment of Niemann-Pick Type C Disease with Potent Inhibitors of Cerebroside Synthase
$40,000 |
|
| 18 | August, 1999 | Leslie P. Henderson
(Dartmouth College, Hanover, New Hampshire, USA) |
Analysis of NPC1 mRNA Expression in the Mouse Brain
$14,592 (Extension of Grant # 10) |
More Details... |
| 17 | July, 1999 | Daniel Ory, M.D.
(Washington University School of Medicine; St. Louis, Missouri, USA) |
Molecular Cloning of NPC2 Gene
$110,000 |
|
| 16 | June, 1999 | Lisa Griffin, M.D., Ph.D.
(University of California - San Francisco; San Francisco, California, USA) |
The Role of Neurosteroids in the Development of Niemann-Pick Type C
$34,000 |
More Details... |
| 15 | June, 1999 | Frederick R. Maxfield, Ph.D.
(Weill Medical College of Cornell University; New York, New York, USA) |
Intracellular Cholesterol Trafficking in Niemann-Pick Type C Disease
$15,000 |
|
| 14 | September, 1998 | Jerry Reagan, Ph.D.
(Wake Forest University School of Medicine; Winston-Salem, North Carolina, USA) |
Acid Sphingomyelinase Regulates Cholesterol Egress from Lysosomes by an Alternative Pathway
$15,000 |
|
| 13 | April, 1998 | Daniel Ory, M.D.
(Washington University School of Medicine; St. Louis, Missouri, USA) |
Molecular Cloning of NPC2 Gene
$60,000 |
|
| 12 | February, 1998 | Jill Morris, Ph.D.
(National Institutes of Health; Bethesda, Maryland, USA) |
Identification of Additional NPC1 Mutations
$31,000 |
More Details... |
| 11 | March, 1998 | Ira Tabas, M.D., Ph.D.
(Columbia University; New York, New York, USA) |
Phospholipid Metabolism and Cholesterol-Induced Cytotoxicity in Niemann-Pick C Macrophages
$15,000 |
|
| 10 | March, 1998 | Leslie P. Henderson, Ph.D.
(Dartmouth College, Hanover, New Hampshire, USA) |
Analysis of NPC1 mRNA Expression in the Mouse Brain
$14,742 |
More Details... |
| 9 | March, 1997 | Marc Patterson, M.D.
(Mayo Clinic; Rochester, Minnesota, USA) |
Lipid Trafficking in the Neurons of NPC Mice
$11,000 |
|
| 8 | January, 1997 | Synthia Mellon, Ph.D.
(University of California - San Francisco; San Francisco, California; USA) |
Potential Involvement of Neurosteroids in the Neurobiological Dysfunctions of NP-C
$30,044 |
More Details... |
| 7 | October, 1996 | Marc Patterson, M.D.
(Mayo Clinic; Rochester, Minnesota, USA) |
Establish an International Registry (database) of NPC Families
$10,213 |
|
| 6 | July, 1996 | G. S. Tint, Ph.D.
(Veterans Adminstration Medical Center; East Orange, New Jersey, USA) |
Accumulation of Oxidized Cholesterol as a Possible Cause of Pathologies Associated with Niemann-Pick Type C Disease
$14,000 |
More Details... |
| 5 | June, 1996 | John R. Sargent, Ph.D.
(University of Stirling; Stirling, Scotland, United Kingdom) |
Influence of Exogenous Fatty Acids on Levels of Cholesterol in Cultured Skin Fibroblasts from NPC Patients
$28,050 |
|
| 4 | January, 1996 | Wenda L. Greer, Ph.D.
(Dalhousie University; Halifax, Nova Scotia, Canada) |
Identification of Niemann-Pick Type D Patients with Arcadian Ancestry as a Step Toward Isolation of the Defective Gene
$12,357 |
More Details... |
| 3 | Nov, 1995 | Charles C. Schwartz, M.D.
(Medical College of Virginia; Richmond, Virginia, USA) |
Quantitation of Cholesterol Transport and Tissue Cholesterol Pool Sizes In Vivo Niemann-Pick Type C Disease
$32,000 |
More Details... |
| 2 | April, 1994 | Laura Liscum, Ph.D.
(Tufts University School of Medicine; Boston, Massachusetts, USA) |
Complementation Analyses of Niemann-Pick Type C Fibroblasts' Cholesterol Transport in Defective CHO Cells
$8,900 |
|
| 1 | 7/1/1993 - 6/30/1997 | Eugene Carstea, Ph.D.
(National Institutes of Health; Bethesda, Maryland, USA) (5 years) |
Identify the Gene Responsible for Niemann-Pick Type C Disease
$160,000 |
More Details... |
| The project status shown above reflects only the Foundation's involvement. A number of the studies listed have been continued or expanded under the sponsorship of NIH and other organizations. |